Discussion about the diagnosis and treatment of QTc Prolongation with Dr. Tom Collins and Dr. Leslie Smoot.
Structural cardiovascular abnormalities occur in 80% of patients with Williams syndrome (WS). The risk of sudden death in patients with WS is significantly higher than the general population. Patients with WS often undergo electrocardiograms (ECGs) and recent research has shown that the QTc interval in WS patients is significantly prolonged. This finding may contribute to the increased risk of sudden death. Patients with WS have also been shown to have increased arrhythmias if their QTc is prolonged.
Tom Collins, MD formerly associated with the Williams Syndrome Clinic at the Children's Hospital of Philadelphia, is an Assistant Professor of Pediatrics and Internal Medicine in the Division of Pediatric Cardiology for the University of Arkansas for Medical Sciences at Arkansas Children's Hospital.
Leslie Smoot, MD is an Assistant in Cardiology specializing in cardimyopathy, cardiac transplantation, cardiovascular genetics and Williams syndrome. Dr. Smoot is the Chairperson of the WS Clinic at Children's Hospital, Boston.