Growth, Body Composition, and Endocrine Issues in Williams Syndrome

Abstract

Purpose of Review:

Williams syndrome (WS) is a multi-system disorder caused by a microdeletion on chromosome 7q. Throughout infancy, childhood, and adulthood, abnormalities in body composition and in multiple endocrine axes may arise for individuals with WS. This review describes the current literature regarding growth, body composition, and endocrine issues in WS with recommendations for surveillance and management by the endocrinologist, geneticist, or primary care physician.

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