The Williams Syndrome Association is made up of people: individuals with Williams syndrome, their families, and interested medical professionals and educators.

Founded by a handful of families in San Diego, CA, the WSA is a volunteer-driven 501(c)(3) non-profit organization divided into 19 regions across the US and Puerto Rico. Each region works to provide social and educational opportunities for its members. The WSA also has an affiliation with similar international groups.

The WSA has supported more than 5,000 families of individuals with WS since its inception.

Formal by-laws provide a framework for the operation and management of the WSA. 

The organization is administered on four levels: